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C60 fullerene electron density

C60 fullerene electron density

Fullerene Hydration

V Water surrounding fullerenes

V Fullerenes containing water

Water surrounding fullerenes

Fullerene hydration is an interesting but lesser known fact concerning the C60 and C70 fullerenes. Contrary to expectations due to their apparently hydrophobic character, they may be dissolved in water. (C60-Ih)[5,6] fullerene can be dispersed in water (> 2 mM [303]) by transferring from an organic solvent using sonication without the need of stabilizers (for example, γ-cyclodextrin [944]) or chemical modification [271] (normally its solubility direct from solid is eleven orders lower at about 20 fM).

 

Graphene

 

Graphene
The positive interactions with water are less surprising in the light of the now-known hydrophilicity of clean young graphene surfaces (see left), where any found hydrophobicity is due to the accumulation of surface hydrocarbon impurities. [2958], which cannot easily occur on the tight spherical surfaces of these fullerenes.

 

It has been found that there are exceptionally strong fullerene-water interactions and rearrangement in the second- and higher-level hydration shells, overbalancing the expected hydrophobic fullerene-fullerene interactions [2122]. C60 fullerene has also been solubilized by ultrasonication in strong aqueous inorganic acids [579] as has C70 [1718]. The result is a kinetically-stable molecular colloidal solution also containing a variety of negatively charged clusters. d It forms a transparent orange solution with a broad absorption band (400-500 nm). This fullerene is an electronegative molecule showing some aromatic behavior in the twenty six-membered (but not the twelve five-membered) rings with the pi-orbitals electron density biased outwards [301]. c C60 has been shown to have a high free energy of hydration and hence a high affinity for water [1851]. An alternative view of fullerene hydration to that given below has been proposed, involving the multiple covalent hydroxylations of C60 [2121], but the mechanism and importance of this process remain unproven. e

 

Comparison of the size of C60 with the water dodecahedron The solubility of single C60 molecules may be explained if the fullerene may sit (ideally) in an icosahedral water cluster (ES) missing its inner water dodecahedron [1183]. The size of the C60 molecule and the central aqueous dodecahedron are similar (see opposite).

 

The inner twenty remaining water molecules are ideally situated to form -OH···pi hydrogen bonds a to each of the twenty 6-membered rings in the fullerene, by positioning directly over these hexagonal rings; the optimum such positioning for the hydrogen bond to a benzene molecule [2534]. The 12 water pentagons possess dipoles with positive charges on the outside and negative charges on the inside whereas the 20 water hexagons possess balancing dipoles with negative charges on the outside and positive charges on the inside; in line with the dipole on corannulene (C20H10) that has a structure similar to any of the 12 caps of C60 molecules [2982]. Thus, each of the 20 negative ends of the local dipoles interacts with a positively charged hydrogen atom from the surrounding water. These 20 water molecules can then be linked through the 60 fully hydrogen-bonded water molecules from the next shell of the icosahedral (ES) cluster. This arrangement would present a negatively charged surface to the environment, as found experimentally. In such a structure the carbon atoms would be centers of electron-deficiency and capable of interacting with lone pair electrons donated by extra water molecules. Such water molecules have room to sit under the outer shell water molecules to which they can hydrogen bond if some outer shell hydrogen bonds are broken or distorted. The strong hydration around the monomeric C60 molecules has been proposed to prevent the occurrence of toxic reactions [687]. b

Hydrated C60 fullerene

 

Hydrated C60 fullerene

 

Support for this structuring has recently come from cross-polarization (CP) nuclear magnetic resonance experiments that have shown that liquid water within about 1 nm of C60 molecules is anisotropic and undergoes a rotational motion that is greatly hindered compared with the motion in the bulk [2110]. The surrounding water in this complex can be partially replaced by disaccharides such as lactose [1904].

 

An increased tendency to ionize by these carbon-linked water molecules would increase the negative charge on the C60 molecules, make the C60 solution acidic as found [303] and give rise to the orange color of solutions. The resultant symmetrical positioning of six hydroxide ions (see below right) increases the electron density so strengthening the -OH···pi-electrons hydrogen bonding. The corresponding hydrogen ions may be associated with the water in the immediately surrounding shell or the bulk.

C60 fullerene (negatively charged by six hydroxide anions) in an icosahedral water cluster

C60(OH-)6(H2O)80

C60 fullerene in an icosahedral water cluster

 

C60(H2O)80

 

In the structures given above only the innermost 80 water molecules in the icosahedral cluster are shown to clarify the structuring. Recent spectroscopic studies are consistent with this structure even though the authors propose C60(H2O)60 [602]. Interactive structures are given (Jmol). Without water hydrogen bonding to the outside of these clusters, they will collapse.

 

Connectivity map showing potential hydroxide sites (blue)

 

Connectivity map showing potential hydroxide sites

 

 

A potential arrangement of six electron-donating hydroxide ions (as above right), shown blue, and the 20 hydrogen atom-donating hydrogen bonds, shown red, is given on the connectivity map of C60; also showing the most important Kekulé structure [946a]. f These 20 positions are also the most prominent positions given by molecular dynamics simulations using a state-of-the-art quantum mechanical polarizable force field [1754].

 

 

C60 molecules in aqueous solution form colloidal clusters based on 3.4 nm-sized icosahedral arrangements of 13 C60 molecules [271], where water separates the C60 molecules [303].

 

 

Cluster of thirteen C60 fullerenes in an

expanded icosahedral aqueous cluster

 

Cluster of thirteen C60 fullerenes in an expanded icosahedral aqueous cluster

 

 

Such an arrangement is shown opposite within an expanded (but now strain-free) cluster of water icosahedral clusters.  The water network is formed by fully tessellated tetrahedral tricyclo decamer (H2O)10 structures (see below for one). The diameter of the cluster (carbon atoms) opposite is slightly larger at 3.5 nm. Ions that destroy the expanded water network also coagulate such C60 hydrosols (see the Hofmeister series) [302].

 

Tetrahedral tricyclo decamer (H2O)10 structure

connecting 4 C60 molecules

Tetrahedral tricyclo decamer (H2O)10 structure connecting 4 C60 molecules

The structure is also compatible with recent findings by Grigoriy Andrievsky using piezo-gravimetry [303] (20 - 24 H2O per C60). This result agrees with low temperature differential calorimetry [305] where two types of water were evident, fully hydrogen-bonded water melting at 0 °C (~60 H2O per C60) showing required hydrogen-bonding to hydrogen-bond deficient water, melting at -2.3 °C (19 ± 1 H2O per C60) with 30% less enthalpy change. The ratio of the inner sphere water molecules to the outer (second) sphere water molecules varies between 1:3 for single molecules and 2:3 for infinite-sized aqueous C60 clusters. Interactive structures are given (Jmol).

 

Even larger clusters form up to about 80 nm diameter, but with water-mediated

···water···C60···water···C60···water····C60···water

interactions rather than hydrophobic clustering

C60····C60····C60····C60

due to the strong C60···water interactions [2122].

 

Theoretical calculations show that a water molecule may be placed inside the (C60-Ih)[5,6] fullerene cage with stabilization (relative to the isolated molecule) due to stronger -OH···π hydrogen bonding than found in the hydration sphere surrounding the fullerene [809]. Although there is room for more water molecules inside the cage, positioning them inside is energetically unfavorable due to poor hydrogen bonding caused by the cramped environment [809].

(C70-D5h(6))[5,6] fullerene can also be dissolved in water [1146]. A solution is achieved using a mixture of sulfuric and nitric acids with or without ultrasonic irradiation. The soluble product proved to be unchanged C70 by mass spectrometry. The hydration of C70 may be similar to that of C60 as above, involving aqueous icosahedral clusters, and utilizing -OH···pi-electrons hydrogen bonds a. In this case the icosahedral water cluster (ES), again missing its inner water dodecahedron, is split into two halves hydrating the top and bottom parts of the C70 (see below). An incomplete hydration shell may form around the middle of the molecule, which naturally involves five water molecules (asterisked below) that are ideally placed to hydrogen bond to the five extra π-centers in the extra five six-membered rings that C70 possesses over the 20 in C60.

 

Inner sphere C70 hydrated by water cluster

Inner sphere C70 hydrated by water cluster

C70 hydrated by water cluster

C70 hydrated by water cluster

Inner aqueous sphere only, C70(H2O)90; C70 shown as blue-green, -OH···pi-electrons hydrogen bonds shown as violet-dashed with hydrogen bonds between the water molecules shown as red links, hydrogen atoms are not shown.

 

Connectivity map of C70

showing H-bonding sites to water cluster

 

Connectivity map of C70 showing H-bonding sites to water cluster

 

 

 

 

The connectivity map for (C70-D5h(6))[5,6] fullerene is shown opposite indicating the electron-rich centers that may hydrogen bond to water in the surrounding aqueous cluster. The blue dots show the positions of the additional sites (compared with (C60-Ih)[5,6]) for hydrogen bonding. It is clear that the -OH···π hydrogen bonds are not equivalent in C70 whereas they were in C60 as there are now three different environments for the electron-rich six-membered rings (in the ratio of 10:10:5).

 

An interactive structure of C70(H2O)90 is given (Jmol).

 

 

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Fullerenes containing water

C60 fullerene containing a water monomer

C60 fullerene containing a water monomer

C70 fullerene containing a water dimer [2517]

C70 fullerene containing a water dimer [2517]

With skill and persistence, water molecules can be placed inside fullerenes dependent on their contained void volume; for example C60H2O (left) and C70(H2O)2 (right) [2516, 2517].

 

The properties of these contained and isolated water molecules are very different from water molecules in bulk phases of water (e.g. [2548]).

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Footnotes

a Such -OH···pi-electrons hydrogen bonds have been found to possess more than half the binding energy of -OH···O hydrogen bonds with, optimally, the -OH atoms centrally and vertically placed and the distances from the oxygen atom to the aromatic centroid of about 3.1-3.7Å (compare 3.2Å for all 20 such bonds/fullerene in the above model) [325]. It has been shown that conversion of a water-water hydrogen bond to a water-benzene hydrogen bond is entropically favored but enthalpically disfavored with about one water-benzene hydrogen bond being formed for each dissolved benzene molecule. They have been found as the optimum structure of C60(H2O) [1068]. Water-benzene -OH···π hydrogen bonds are evident below 340 °C [945, 2248] and are responsible for the higher than the expected solubility of benzene in water [2430]. [Back]

 

b Although disputed from some quarters, the toxicity widely reported for some C60 preparations may be solely due to the presence of significant amounts of solvent or impurities [687]. Tests for physiological harm should be experimental as modeling studies may ignore this hydration effect (for example, [956]). Other work has shown that hydrated fullerene may have some health benefit [1317]. [Back]

 

c Although C60 has been modeled (by some) as a purely hydrophobic structure possessing no electrostatic interactions, it is important to recognize that there are effective charge separations between the (positive) carbon atoms and the (negative) centers of the six-membered rings and also that the C60 molecule is polarizable. Without allowing for these factors, such modeling is likely to be unreliable. [Back]

 

 

C60(OH)24

 

C60(OH)24

 

d Other work only produces colloidal clusters [1370]. [Back]

 

e A derivative of the C60 fullerene, C60(OH)24 (see right) dissolves and hydrates well in water. In this molecule the hydroxyl groups are closely arranged and encourage high-density water forming around the fullerene, with limited (but strong) hydrogen bonding to the hydroxyl groups (<2 per OH group compared with the preferred hydration of 3 per OH group) and consequentially there are many broken hydrogen bonds in the surrounding water [1370]. It has been proposed that this structure may be formed during extensive ultrasonication and is responsible for the solubility of C60 [2121]. [Back]

 

f The 30 double bonds actually have bond orders of 1.44 and the 60 single bonds (all 12 pentagons) have bond orders of 1.28, so using the 'spare' Pz electrons donated from each of the 60 carbon atoms [946b]. [Back]

 

 

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